• Soheila Rezapour-Firouzi, Seyed Rafie Arefhosseini, Mehrangiz Ebrahimi-Mamaghani, Behzad Baradaran, Elyar Sadeghihokmabad, Mohammadali Torbati, Somaiyeh Mostafaei, Mahtaj Chehreh, and Fatemeh Zamani.
• Neurosciences Research Center, University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, University of Medical Sciences, Tabriz, Iran. Electronic address: s.rfirozi@gmail.com.
• Complement Ther Med. 2014 Dec 1; 22 (6): 986-93.

BackgroundIt is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for multiple sclerosis disease. This study assesses alanine amino-transferase (ALT), aspartate-aminotransferase (AST) and gamma-glutamyl transferase (GGT) activities in MS patients treated with co-supplemented hemp seed and evening primrose oils as well as Hot-nature diet and the therapeutic potential this intervention.Methods And MaterialsIn this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "group A", who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet; "group B",who received olive oil; and "group C", who received the co-supplemented oils. Clinically, EDSS as well as serum level of liver enzymes (GGT, AST, and ALT) were assessed at baseline and after 6 months.ResultsMean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration of 6.80±4.33 years). There was no significant difference in the study parameters at baseline. Serum levels of liver enzymes (GGT, AST, and ALT) were serially monitored. Intervention was associated with liver function alteration in three groups. Significance decreased in EDSS score and the levels of liver enzymes were found in groups A and C, whereas elevated serum liver enzymes and EDSS score were observed in group B after the intervention.ConclusionSelecting foods according to their Total antioxidant capacity such as co-supplemented hemp seed and evening primrose oils with Hot-nature diet affects antioxidant intake and can have beneficial effects on improving EDSS score and activity of liver enzymes in RRMS patients.Copyright © 2014 Elsevier Ltd. All rights reserved.

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