• Internal medicine journal · Dec 2012

    Case Reports

    Successful treatment of macrophage activation syndrome complicating adult Still disease with anakinra.

    • N K Loh, M Lucas, S Fernandez, and D Prentice.
    • Department of Internal Medicine, Royal Perth Hospital, Perth, Western Australia, Australia. nelson.loh@health.wa.gov.au
    • Intern Med J. 2012 Dec 1; 42 (12): 1358-62.

    AbstractA previously healthy 20-year-old man presented with adult Still disease (ASD). He developed life-threatening macrophage activation syndrome (MAS), which was refractory to standard immunosuppression but responded dramatically to the IL-1 receptor antagonist anakinra. Subsequent immunological investigations included assessment of the perforin expression of natural killer (NK) cells and CD8+ T cells, which confirmed MAS.© 2012 The Authors; Internal Medicine Journal © 2012 Royal Australasian College of Physicians.

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