• Am. J. Med. Genet. B Neuropsychiatr. Genet. · Apr 2018

    Emotional and behavioral problems in children and adolescents with neurofibromatosis type 1.

    • André B Rietman, Thijs van der Vaart, Ellen Plasschaert, Bethany A Nicholson, Rianne Oostenbrink, Lianne C Krab, Mie-Jef Descheemaeker, Wit Marie-Claire Y de MY ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands. , Henriëtte A Moll, Eric Legius, and Nijs Pieter F A de PFA ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands. .
    • ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus MC - Sophia Children's Hospital, Rotterdam, the Netherlands.
    • Am. J. Med. Genet. B Neuropsychiatr. Genet. 2018 Apr 1; 177 (3): 319-328.

    AbstractTo assess emotional and behavioral problems in children and adolescents with neurofibromatosis type 1,parents of 183 individuals aged 10.8 ± 3.1 years (range 6-17) completed the Child Behavior Checklist (CBCL). Also, 173 teachers completed the Teacher's Report Form (TRF), and 88 adolescents (children from 11 to 17 years) completed the Youth Self-Report (YSR). According to parental ratings, 32% scored in the clinical range (above the 90th percentile). This percentage was much lower when rated by teachers or adolescents themselves. Scores from all informants on scales for Somatic complaints, Social problems, and Attention problems were significantly different from normative scores. Attentional problems were associated with lower verbal IQ, male gender, younger age, and ADHD-symptoms. Disease-related factors did not predict behavioral problems scores. Substantial emotional and behavioral problems were reported by parents, teachers, and to a lesser extent by adolescents with NF1 themselves. Possibly, a positive illusory bias affects the observation of behavioral problems by adolescents with NF1.© 2017 Wiley Periodicals, Inc.

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