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Ugeskrift for laeger · Mar 2006
Randomized Controlled Trial Comparative Study[Reduced post-partum bleeding after treatment with sublingual misoprostol: a randomized double-blind clinical study in a developing country--secondary publication)].
- Birgitte Bruun Nielsen, Lars Høj, Lone Egly Hvidman, Jens Nielsen, Placido Cardoso, and Peter Aaby.
- Arhus Universitetshospital, Skejby Sygehus, Gynaekologisk-obstetrisk Afdeling Y, og Statens Serum Institut, Afdelingen for Epidemiologisk Forskning. birgitte.bruun.nielsen@dadlnet.dk
- Ugeskr. Laeg. 2006 Mar 27; 168 (13): 1341-3.
AbstractPost-partum haemorrhage is the most common cause of maternal death in third-world countries. The objective of this study was to evaluate whether routine administration of sublingual misoprostol, 600 g, reduces post-partum haemorrhage. Significantly fewer women in the misoprostol group experienced a loss of > or = 1,000 ml (11% vs. 17%; 0.66 (0.45-0.98)) or > or = 1,500 ml (2% vs. 8%; 0.28 (0.12-0.64)) of blood. We conclude that sublingual misoprostol reduces the frequency of severe post-partum haemorrhage.
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