• Clin. Orthop. Relat. Res. · Nov 1980

    Uptake of glycosaminoglycan polysulfate by articular and meniscus cartilage: a biochemical and autoradiographic investigation.

    • H Iwata, M Kaneko, K Kawai, G Kajino, and M Nakagawa.
    • Clin. Orthop. Relat. Res. 1980 Nov 1 (153): 265-72.

    AbstractIncorporation of labeled glycosaminoglycan polysulfate (35S-GPS) into the knee joint was studied biochemically and autoradiographically. After an injection into a knee joint of a rabbit, 35S-GPS was taken up into articular and meniscus cartilage. A 35S-GPS macromolecule and a complex of 4 M GuHCl extracted soluble substance (mainly considered proteoglycan) exists in the articular and meniscus cartilages. A free sulfate, that is, desulfated 35S-GPS, is not incorporated during proteoglycan synthesis. The 35S-GPS remains longer in meniscus cartilage than in articular cartilage. Immediately after intra-articular administration of 35S-GPS, a high grain count was observed in autoradiographs of the perichondrium and the superficial layer of articular cartilage of rats. One day after injection of 35S-GPS, numerous grains were observed in the deep layer. Autoradiography also demonstrated that 35S-GPS turnover is greater in articular cartilage than in meniscus. Uptake of 35S-GPS in an unmodified form in extracellular matrix of articular cartilage should be further investigated in experimental animals with degenerative osteoarthritis.

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