• Aliye Bastug, Hurrem Bodur, Serpil Erdogan, Derya Gokcinar, Sumeyye Kazancioglu, Behiye Deniz Kosovali, Bahadır Orkun Ozbay, Gamze Gok, Isil Ozkocak Turan, Gulsen Yilmaz, Canan Cam Gonen, and Fatma Meric Yilmaz.
• Department of Infectious Diseases and Clinical Microbiology, Health Science University Turkey, Ankara City Hospital, 06800 Ankara, Turkey. Electronic address: dr.aliye@yahoo.com.
• Int. Immunopharmacol. 2020 Nov 1; 88: 106950.

BackgroundCoronavirus disease 2019 (COVID-19) emerged first in December 2019 in Wuhan, China and quickly spread throughout the world. Clinical and laboratory data are of importance to increase the success in the management of COVID-19 patients.MethodsData were obtained retrospectively from medical records of 191 hospitalized patients diagnosed with COVID-19 from a tertiary single-center hospital between March and April 2020. Prognostic effects of variables on admission among patients who received intensive care unit (ICU) support and those who didn't require ICU care were compared.ResultsPatients required ICU care (n = 46) were older (median, 71 vs. 43 years), with more underlying comorbidities (76.1% vs. 33.1%). ICU patients had lower lymphocytes, percentage of large unstained cell (%LUC), hemoglobin, total protein, and albumin, but higher leucocytes, neutrophils, neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocytes ratio (PLR), urea, creatinine, aspartate amino transferase (AST), lactate dehydrogenase (LDH), and D-dimer when compared with non-critically ill patients (p < 0.001). A logistic regression model was created to include ferritin, %LUC, NLR, and D-dimer. %LUC decrease and D-dimer increase had the highest odds ratios (0.093 vs 5.597, respectively) to predict severe prognosis. D-dimer, CRP, and NLR had the highest AUC in the ROC analysis (0.896, 0.874, 0.861, respectively).ConclusionsThe comprehensive analysis of clinical and admission laboratory parameters to identify patients with severe prognosis is important not only for the follow-up of the patients but also to identify the pathophysiology of the disease. %LUC decrease and D-dimer, NLR, and CRP increases seem to be the most powerful laboratory predictors of severe prognosis.Copyright © 2020 Elsevier B.V. All rights reserved.

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