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- Thomas P Lodise, Rohit Mistry, Kate Young, and Kenneth LaPensee.
- Albany College of Pharmacy and the Health Sciences, 106 New Scotland Avenue, Albany, NY, 12189, USA. Thomas.Lodise@acphs.edu.
- Clin Drug Investig. 2021 Mar 1; 41 (3): 269-275.
BACKGROUND AND ObjectiveOmadacycline is an aminomethylcycline antibiotic approved in the USA as once-daily intravenous/oral monotherapy for adults with community-acquired bacterial pneumonia (CABP). Omadacycline demonstrated noninferiority to the fluoroquinolone moxifloxacin in a phase III CABP trial; adverse-event rates were similar between treatment groups except for Clostridioides difficile infection (CDI), which occurred in 2% of moxifloxacin-treated patients and 0% of patients on omadacycline. Conceptual healthcare-decision analytic models were developed to better understand the economic implications of antibiotic selection and CDI risk in acute-care facilities.
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