• Epileptic Disord · Mar 2006

    Case Reports

    EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome.

    • Kenichi Kikumoto, Harumi Yoshinaga, Makio Oka, Minako Ito, Fumika Endoh, Tomoyuki Akiyama, and Yoko Ohtsuka.
    • Department of Child Neurology, Okayama University, Japan. kkikumoto@mac.com
    • Epileptic Disord. 2006 Mar 1; 8 (1): 53-6.

    AbstractWe report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine. Soon after the introduction of carbamazepine, EEGs began to worsen, and finally absence seizures and myoclonic seizures appeared. Immediately after we discontinued carbamazepine, the seizures disappeared and the EEG improved. Carbamazepine may induce unusual electroclinical features, electrophysiologically explained by bilateral synchrony. This case provides more evidence of the close links between Panayiotopoulos syndrome and benign childhood epilepsy with centrotemporal spikes.

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