• Am. J. Transplant. · Mar 2007

    Clinical Trial

    Clobetasol ameliorates aphthous ulceration in renal transplant patients on sirolimus.

    • P Chuang and A J Langone.
    • Department of Medicine, Division of Nephrology and Hypertension, Vanderbilt University Medical Center, S-3223 Medical Center North, Nashville, TN 37232, USA. pealechuang@hotmail.com
    • Am. J. Transplant. 2007 Mar 1; 7 (3): 714-7.

    AbstractAphthous ulceration is a common side effect of sirolimus. These lesions of the oral mucous membranes are often painful and debilitating, leading to either dose reduction or discontinuation of sirolimus in a significant number of patients. We report that the direct application of clobetasol, a high potency topical steroid, led to prompt resolution of the aphthous ulcers that developed in our renal transplant patients on sirolimus-based immunosuppression.

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