• Thorax · Nov 2020

    Observational Study

    High-flow nasal cannula oxygen therapy to treat patients with hypoxemic acute respiratory failure consequent to SARS-CoV-2 infection.

    • Andrea Vianello, Giovanna Arcaro, Beatrice Molena, Cristian Turato, Andi Sukthi, Gabriella Guarnieri, Francesca Lugato, Gianenrico Senna, and Paolo Navalesi.
    • Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy andrea.vianello@aopd.veneto.it.
    • Thorax. 2020 Nov 1; 75 (11): 998-1000.

    AbstractThis observational study aims to assess the outcome and safety of O2-therapy by high-flow nasal cannula (HFNC) in 28 consecutive patients with severe hypoxemic acute respiratory failure (hARF) consequent to SARS-CoV-2 infection, unresponsive to conventional O2-therapy. Nineteen patients had a positive response. Nine patients required escalation of treatment to non-invasive ventilation (five subsequently intubated). None of the staff had a positive swab testing during the study period and the following 14 days. Severity of hypoxemia and C reactive protein level were correlated with HFNC failure. These data suggest HFNC to be a safe treatment for less severe patients with SARS-CoV-2 hARF and efficacy will need to be assessed as part of a clinical trial.© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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