• Am. J. Cardiol. · May 2012

    Multicenter Study Comparative Study

    Comparison of complications and outcomes to one year of transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis.

    • Corrado Tamburino, Marco Barbanti, Davide Capodanno, Carmelo Mignosa, Maurizio Gentile, Patrizia Aruta, Anna Maria Pistritto, Claudio Bonanno, Salvatore Bonura, Alessandra Cadoni, Simona Gulino, Maria Concetta Di Pasqua, Valeria Cammalleri, Marilena Scarabelli, Massimiliano Mulè, Sebastiano Immè, Del Campo Giuliana G, and Gian Paolo Ussia.
    • Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy.
    • Am. J. Cardiol. 2012 May 15; 109 (10): 1487-93.

    AbstractComparisons of transcatheter aortic valve implantation (TAVI) to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis remain sparse or limited by a short follow-up. We sought to evaluate early and midterm outcomes of consecutive patients (n = 618) undergoing successful TAVI (n = 218) or isolated SAVR (n = 400) at 2 centers. The primary end point was incidence of Valvular Academic Research Consortium-defined major adverse cerebrovascular and cardiac events (MACCEs) up to 1 year. Control of potential confounders was attempted with extensive statistical adjustment by covariates and/or propensity score. In-hospital MACCEs occurred in 73 patients (11.8%) and was more frequent in patients treated with SAVR compared to those treated with TAVI (7.8% vs 14.0%, p = 0.022). After addressing potential confounders using 3 methods of statistical adjustment, SAVR was consistently associated with a higher risk of MACCEs than TAVI, with estimates of relative risk ranging from 2.2 to 2.6 at 30 days, 2.3 to 2.5 at 6 months, and 2.0 to 2.2 at 12 months. This difference was driven by an adjusted increased risk of life-threatening bleeding at 6 and 12 months and stroke at 12 months with SAVR. Conversely, no differences in adjusted risk of death, stroke and myocardial infarction were noted between TAVI and SAVR at each time point. In conclusion, in a large observational registry with admitted potential for selection bias and residual confounding, TAVI was not associated with a higher risk of 1-year MACCEs compared to SAVR.Copyright © 2012 Elsevier Inc. All rights reserved.

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