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- Yukihiro Yamao, Riki Matsumoto, Takayuki Kikuchi, Kazumichi Yoshida, Takeharu Kunieda, and Susumu Miyamoto.
- Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
- Front Hum Neurosci. 2021 Jan 1; 15: 635453.
AbstractTo preserve postoperative brain function, it is important for neurosurgeons to fully understand the brain's structure, vasculature, and function. Intraoperative high-frequency electrical stimulation during awake craniotomy is the gold standard for mapping the function of the cortices and white matter; however, this method can only map the "focal" functions and cannot monitor large-scale cortical networks in real-time. Recently, an in vivo electrophysiological method using cortico-cortical evoked potentials (CCEPs) induced by single-pulse electrical cortical stimulation has been developed in an extraoperative setting. By using the CCEP connectivity pattern intraoperatively, mapping and real-time monitoring of the dorsal language pathway is available. This intraoperative CCEP method also allows for mapping of the frontal aslant tract, another language pathway, and detection of connectivity between the primary and supplementary motor areas in the frontal lobe network. Intraoperative CCEP mapping has also demonstrated connectivity between the frontal and temporal lobes, likely via the ventral language pathway. Establishing intraoperative electrophysiological monitoring is clinically useful for preserving brain function, even under general anesthesia. This CCEP technique demonstrates potential clinical applications for mapping and monitoring large-scale cortical networks.Copyright © 2021 Yamao, Matsumoto, Kikuchi, Yoshida, Kunieda and Miyamoto.
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