• Antimicrob. Agents Chemother. · Apr 2006

    Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.

    • William R Kirkpatrick, Brent J Coco, and Thomas F Patterson.
    • The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, TX 78229-3900, USA. kirkpatrick@uthscsa.edu
    • Antimicrob. Agents Chemother. 2006 Apr 1; 50 (4): 1567-9.

    AbstractWe evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

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