• Thirunavukkarasu Sandeep, Mysore Subrahmanyam Roopakala, Chickballapur Rayappa Wilma Delphine Silvia, Srikantaiah Chandrashekara, and Mohan Rao.
• Department of Physiology, MS Ramaiah Medical College, Bangalore - 560054, India.
• Lung India. 2010 Jul 1; 27 (3): 138-40.

BackgroundImmunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthmaAimTo estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma.Materials And MethodsA stratified sample of 60 patients within age group of 18-60 years and 31 male and 29 female asthmatic patients and 13 healthy controls within 18-60 years were included in this study and classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit.ResultsMean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics. The model developed was 27% efficient.ConclusionSerum Immunoglobulin E levels were high in asthmatics as compared to normal subjects. On an average, the levels increased as the severity of asthma increased. However, there was no statistically significant correlation since the variability in each level of asthma was very large.

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