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Zhonghua Wai Ke Za Zhi · Sep 1995
[Effects of thermal injury on production of nitric oxide in rat heart].
- J Huan, Y Han, and Y Chen.
- Burn Institute, Changhai Hospital, Shanghai.
- Zhonghua Wai Ke Za Zhi. 1995 Sep 1; 33 (9): 568-70.
AbstractTo elucidate the relationship between thermal injury and production of nitric oxide (NO), we measured the levels of heart No2-/NO3- (the stable and products of NO) and GMP in rats with full thickness burn of 30% TBSA. A higher level of heart tissue NO2-/NO3- was observed from 3 to 24 hours after burn injury. Parallel to the changes of NO2-/NO3-, there were increases of tissue cGMP level and heart tissue water content in burned rats. L-NMMA, a specific inhibitor of NO synthetase (NOS), can block the rise of heart NO2-/NO3- and the enhancement of heart water content. The results indicate that the heart injury caused by burn injury may be associated with induction of NOS and formation of NO.
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