• K P Kelly, B J Stenson, and G B Drummond.
• The University Department of Anaesthetics, The Royal Infirmary of Edinburgh, UK. Keith.Kelly@ed.ac.uk
• Intensive Care Med. 2000 Oct 1; 26 (10): 1523-30.

ObjectiveTo compare gas exchange, lung mechanics, and survival to 12 h in surfactant-depleted lung-injured rabbits, treated with partial liquid ventilation (PLV) with perfluorocarbon, nebulised perfluorocarbon, and porcine or artificial surfactant.DesignProspective randomised controlled study.SettingAnimal laboratory, University of Edinburgh, UK.SubjectsEighty-two adult female New Zealand white rabbits with surfactant deficiency and acute lung injury induced by repeated saline lavage.InterventionsAnimals were randomised to one of seven treatments: (a) control (n = 20); (b) PLV with perfluorocarbon PF 5080 (n = 12); (c) nebulised PF 5080 (n = 10); (d) artificial surfactant (n = 10); (e) porcine surfactant (n = 10); (f) artificial surfactant+PLV (n = 10); (g) porcine surfactant+PLV (n = 10).Measurements And Main ResultsArterial blood gases and dynamic compliance (Cdyn) were measured hourly until 12 h. Oxygenation was improved by PLV, porcine surfactant, porcine surfactant+PLV and artificial surfactant+PLV. Cdyn improved after treatment with PLV, porcine surfactant and PLV+porcine surfactant. Survival was greater with PLV and artificial surfactant+PLV. Neither nebulised PF 5080 nor artificial surfactant had a detectable effect.ConclusionsPLV, porcine surfactant and combinations of surfactant with PLV improved oxygenation, Cdyn and survival, but none was clearly superior to the others.

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