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- Hua Jiang, Xusheng Qiu, Jin Dai, Huang Yan, Zezhang Zhu, Bangping Qian, and Yong Qiu.
- Department of Spine Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Zhongshan Road No 321, 210008 Nanjing, China.
- Eur Spine J. 2013 Feb 1; 22 (2): 282-6.
PurposeTo investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.MethodsA total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only study were performed to define the contribution of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.ResultsA significant association of rs11190870 with AIS was observed in the Han Chinese population (P = 1.8 × 10(-9); odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.ConclusionsThe SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.
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