• Am. J. Hematol. · Oct 2000

    Review

    Pathophysiology of the catastrophic antiphospholipid syndrome (CAPS).

    • D A Triplett and R A Asherson.
    • Midwest Hemostasis and Thrombosis Laboratories, Ball Memorial Hospital, Muncie, Indiana 47303, USA. dtriplett@cami3.com
    • Am. J. Hematol. 2000 Oct 1; 65 (2): 154-9.

    AbstractAntiphospholipid antibodies (APA) are a common cause of acquired thrombophilia. APA recognize plasma phospholipid-binding proteins (e. g., beta(2)-glycoprotein I, prothrombin, annexin V, etc.). Catastrophic antiphospholipid syndrome (CAPS) is an uncommon variant of the antiphospholipid syndrome. CAPS patients often present with multiorgan failure. Precipitating factors include surgical procedures, drugs, and discontinuation of anticoagulant therapy. Increasingly, infections are recognized as a major precipitating condition. The majority of patients present with renal involvement as well as evidence of acute respiratory distress syndrome (ARDS). This review discusses the clinical and pathophysiologic aspects of CAPS as well as the differenital diagnosis.Copyright 2000 Wiley-Liss, Inc.

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