• Jianyuan Jin, Chengshuang Pan, Qianjin Fei, Wuhua Ni, Xu Yang, Liya Zhang, and Xuefeng Huang.
• Reproductive Medicine Center, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
• Fertil. Steril. 2015 Apr 1; 103 (4): 910-6.

ObjectiveTo investigate effect of sperm DNA fragmentation (SDF) on clinical outcomes of assisted reproductive technology in women with normal ovarian reserve (NOR) versus reduced ovarian reserve (ROR).DesignRetrospective clinical study.SettingUniversity-affiliated tertiary teaching hospital.Patient(S)A total of 2,865 consecutive couples undergoing their first in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycle.Intervention(S)SDF assessed using sperm chromatin dispersion in sperm samples 1-2 months before treatment.Main Outcome Measure(S)SDF, IVF, and ICSI outcomes.Result(S)The grouping criteria were [1] basal follicle stimulating hormone >10 IU/L, [2] antral follicle count <6, and [3] female age ≥38 years. Women fulfilling two of the three criteria were considered to have ROR, and those not meeting any criteria were considered to have NOR. The area under the receiver operating characteristic curve was 0.594 (0.539-0.648) for the ROR group and 0.510 (0.491-0.530) for the NOR group. A cutoff value for SDF to predict the clinical pregnancy rate (CPR) in the ROR group was 27.3%. When the SDF exceeded 27.3%, the live-birth and implantation rates in the ROR group were statistically significantly decreased, but the clinical pregnancy, live-birth, and implantation rates were not affected in the NOR group. The risk of early abortion increased significantly in the NOR group when the SDF exceeded 27.3%.Conclusion(S)Sperm DNA fragmentation has a greater impact on IVF and ICSI outcomes among women with ROR, so SDF testing may be of particular clinical significance for these couples.Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

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