• Expert Opin Pharmacother · Mar 2008

    Review

    Ropinirole treatment for restless legs syndrome.

    • Richard K Bogan.
    • SleepMed of South Carolina, 1333 Taylor St, Suite 6B, Columbia, SC 29201, USA. rbogan@sleepmed.md
    • Expert Opin Pharmacother. 2008 Mar 1; 9 (4): 611-23.

    BackgroundRestless legs syndrome (RLS) is a chronic neurological disorder associated with sleep disturbance.ObjectivePrepare a drug evaluation of the non-ergot dopamine agonist ropinirole in RLS.MethodsReview of scientific literature on RLS, particularly focusing on treatment with ropinirole.ConclusionRopinirole has been studied for treatment of moderate to severe primary RLS in a comprehensive clinical development program. Ropinirole significantly improved symptoms of RLS, versus placebo, in patients with primary RLS. These improvements are supported by data from individual studies and pooled analyses. Significant improvements in RLS symptoms were observed within two nights of treatment. Ropinirole also produced significant benefits on objective measures of RLS motor symptoms, such as periodic leg movements, and subjective measures of sleep. Ropinirole was generally well tolerated.

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