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Nature neuroscience · Jun 2009
Long-term plasticity of excitatory inputs to granule cells in the rat olfactory bulb.
- Yuan Gao and Ben W Strowbridge.
- Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio, USA.
- Nat. Neurosci. 2009 Jun 1; 12 (6): 731-3.
AbstractUsing two photon-guided focal stimulation, we found spike timing-dependent plasticity of proximal excitatory inputs to olfactory bulb granule cells that originated, in part, from cortical feedback projections. The protocol that potentiated proximal inputs depressed distal, dendrodendritic inputs to granule cells. Granule cell excitatory postsynaptic potentials and mitral cell inhibition were also potentiated by theta-burst stimulation. Plasticity of cortical feedback inputs to interneurons provides a mechanism for encoding information by modulating bulbar inhibition.
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