• J. Thromb. Haemost. · May 2017

    Comparative Study

    Incomplete reversibility of platelet inhibition following prolonged exposure to ticagrelor.

    • A J Gerrits, J A Jakubowski, A Sugidachi, A D Michelson, and A L Frelinger.
    • Center for Platelet Research Studies, Division of Hematology/Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
    • J. Thromb. Haemost. 2017 May 1; 15 (5): 858-867.

    AbstractEssentials Irreversible platelet inhibition persists after reversibly-binding ticagrelor is discontinued. Reversibility of platelet inhibition by ticagrelor and its active metabolite was assessed. Incomplete recovery was observed after prolonged exposure to ticagrelor. Activated GPIIb-IIIa and P-selectin, not platelet reactivity index, showed irreversibility.© 2017 International Society on Thrombosis and Haemostasis.

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