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Cahiers d'anesthésiologie · Jan 1995
Randomized Controlled Trial Comparative Study Clinical Trial[Hemodynamic effect of intrathecal clonidine].
- L Rubin, P Koeberlé, K Bachour, G Bettinger, and F Barale.
- Service d'Anesthésie-Réanimation chirurgicale, CHU Saint-Jacques, Besançon.
- Cah Anesthesiol. 1995 Jan 1; 43 (3): 307-12.
AbstractIntrathecal administration of bupivacaine and clonidine results in a significant prolongation of both motor and sensitive blocks but side effects-hypotension and bradycardia-are observed. We compared two groups of patients allocated randomly. One group received intrathecal bupivacaine-morphine and the other one received clonidine-bupivacaine-morphine. In the group which received clonidine a blood pressure decrease was observed from 2nd to 8th hour, independently from the sympathetic block and easily corrected by i.v. ephedrine. Some possible explanations are discussed. No complications due to clonidine were observed.
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