• World Neurosurg · Feb 2015

    Review

    Olfactory ensheathing cells: Part II--source of cells and application to patients.

    • David Choi and Karen Gladwin.
    • Department of Brain, Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, United Kingdom; National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address: d.choi@ucl.ac.uk.
    • World Neurosurg. 2015 Feb 1;83(2):251-6.

    ObjectiveTo assess clinical methods of sourcing human olfactory ensheathing cells (OECs), and the results of present day clinical studies in OEC transplantation.MethodsReview of literature.ResultsPresent clinical studies of OEC transplantation have demonstrated the feasibility and safety of the technique, and no significant complications have occurred from harvest of the olfactory mucosa to culture OECs. These reported studies have not been designed to determine whether clinical outcome is improved by transplantation.ConclusionsOEC transplantation strategies need to be studied further. At present clinical models for testing OECs vary in methodology and quality, and until high-quality, well-designed, and sufficiently powered studies have been performed, the true effect of OEC treatment for patients will remain unclear.Copyright © 2015 Elsevier Inc. All rights reserved.

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