• Medicina · Apr 2021

    Review

    The Usefulness of Lymphadenectomy in Bladder Cancer-Current Status.

    • Bartosz Małkiewicz, Paweł Kiełb, Adam Gurwin, Klaudia Knecht, Karol Wilk, Jakub Dobruch, and Romuald Zdrojowy.
    • Department of Urology and Oncologic Urology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
    • Medicina (Kaunas). 2021 Apr 25; 57 (5).

    AbstractThe purpose of this review is to present the current status of lymph node dissection (LND) during radical cystectomy in patients with bladder cancer (BCa). Despite the growing body of evidence of LND utility at the time of radical cystectomy (RC) in high-risk nonmuscle-invasive and muscle-invasive BCa (MIBC), therapeutic and prognostic value and optimal extent of LND remain unsolved issues. Recently published results of the first prospective, a randomized trial assessing the therapeutic benefit of extended versus limited LND during RC, failed to demonstrate survival improvement with the extended template. Although LND is the most accurate staging procedure, the direct therapeutic effect is still not evident from the current literature, limiting the possibility of establishing clear recommendations. This indicates the need for robust and adequately powered clinical trials.

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