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- Sangmi S Park, Romy Rodriguez Ortega, Christina W Agudelo, Jessica Perez Perez, Brais Perez Gandara, Itsaso Garcia-Arcos, Cormac McCarthy, and Patrick Geraghty.
- Department of Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA.
- Medicina (Kaunas). 2021 Apr 20; 57 (4).
AbstractAlpha-1 antitrypsin (AAT) has established anti-inflammatory and immunomodulatory effects in chronic obstructive pulmonary disease but there is increasing evidence of its role in other inflammatory and immune-mediated conditions, like diabetes mellitus (DM). AAT activity is altered in both developing and established type 1 diabetes mellitus (T1DM) as well in established type 2 DM (T2DM). Augmentation therapy with AAT appears to favorably impact T1DM development in mice models and to affect β-cell function and inflammation in humans with T1DM. The role of AAT in T2DM is less clear, but AAT activity appears to be reduced in T2DM. This article reviews these associations and emerging therapeutic strategies using AAT to treat DM.
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