• Ann. Oncol. · Nov 2003

    Clinical Trial Controlled Clinical Trial

    Sequential transarterial chemoembolization and percutaneous acetic acid injection therapy versus repeated percutaneous acetic acid injection for unresectable hepatocellular carcinoma: a prospective study.

    • T-I Huo, Y-H Huang, J-C Wu, J-H Chiang, P-C Lee, F-Y Chang, and S-D Lee.
    • Department of Medicine, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China. tihuo@vghtpe.gov.tw
    • Ann. Oncol. 2003 Nov 1; 14 (11): 1648-53.

    BackgroundTransarterial chemoembolization (TACE) and percutaneous acetic acid injection (PAI) are effective treatments for hepatocellular carcinoma (HCC). We have conducted a prospective study to compare the efficacy of sequential TACE and PAI (TACE-PAI) versus repeated PAI therapy for HCC.Patients And MethodsA total of 108 HCC patients with tumor size ResultsObjective responses were achieved in 72 of 80 nodules (90%) in the TACE-PAI group compared with 51 of 62 nodules (82%) in the PAI group (P = 0.217) during 24 +/- 10 months of follow-up. Patients in the TACE-PAI group had a significantly lower cumulative tumor recurrence rate from the treated nodule (P = 0.004) or newly developed tumor elsewhere in liver (P = 0.010). Complete tumor necrosis in large (3-5 cm) HCCs was more frequently encountered in the TACE-PAI group (64% versus 37%; P = 0.034). There was no significant survival difference between the two groups with small (ConclusionsSequential therapy with TACE and PAI is superior to repeated PAI alone for patients with large HCC.

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