• Vaccine · Jul 2006

    Randomized Controlled Trial Multicenter Study

    Immunologic responses following administration of a vaccine targeting human papillomavirus Types 6, 11, 16, and 18.

    • Luisa L Villa, Kevin A Ault, Anna R Giuliano, Ronaldo L R Costa, Carlos A Petta, Rosires P Andrade, Darron R Brown, Alex Ferenczy, Diane M Harper, Laura A Koutsky, Robert J Kurman, Matti Lehtinen, Christian Malm, Sven-Eric Olsson, Brigitte M Ronnett, Finn Egil Skjeldestad, Margareta Steinwall, Mark H Stoler, Cosette M Wheeler, Frank J Taddeo, Jimmy Yu, Lisa Lupinacci, Radha Railkar, Rocio Marchese, Mark T Esser, Janine Bryan, Kathrin U Jansen, Heather L Sings, Gretchen M Tamms, Alfred J Saah, and Eliav Barr.
    • Department of Virology, Ludwig Institute for Cancer Research, R. Prof. Antonio Prudente 109, 4th floor, 01509-010 Sao Paulo, SP, Brazil. llvilla@ludwig.org.br
    • Vaccine. 2006 Jul 7; 24 (27-28): 5571-83.

    AbstractHuman papillomavirus (HPV) infection causes cervical cancer and genital warts. Young women (1106) were randomized to receive one of three formulations of a quadrivalent HPV (Types 6/11/16/18) L1 virus-like particle (VLP) vaccine or one of two placebo formulations. The goal was to assess vaccine safety and immunogenicity in baseline HPV 6/11/16 or 18-naïve and previously infected subjects. All three formulations were highly immunogenic. At Month 2 (postdose 1), among women with vaccine-type antibodies at baseline, vaccine-induced anti-HPV responses were approximately 12- to 26-fold higher than those observed in baseline-naïve women, suggesting an anamnestic response. Following an initial, similar sized decline, anti-HPV responses plateaued and remained stable through end-of-study (3.0 years). No vaccine-related serious adverse experiences were reported.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…