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- Allan Donner and Neil Klar.
- Department of Epidemiology and Biostatistics, The University of Western Ontario, London, Ontario, N6A 5C1, Canada. donner@biostats.uwo.ca
- Stat Med. 2002 Oct 15; 21 (19): 2971-80.
AbstractMeta-analyses involving the synthesis of evidence from cluster randomization trials are being increasingly reported. These analyses raise challenging methodologic issues beyond those raised by meta-analyses which include only individually randomized trials. In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods.Copyright 2002 John Wiley & Sons, Ltd.
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