• Clinical biochemistry · Dec 2020

    Review

    Canadian society of clinical chemists (CSCC) interim consensus guidance for testing and reporting of SARS-CoV-2 serology.

    • Dana Bailey, Danijela Konforte, Vilte E Barakauskas, Paul M Yip, Vathany Kulasingam, Mohamed Abou El Hassan, Lori A Beach, Ivan M Blasutig, Peter Catomeris, Kent C Dooley, Yanping Gong, Peter Kavsak, Edward W Randell, Jason L Robinson, Julie Shaw, Jennifer Taher, and Nicole White-Al Habeeb.
    • Dynacare, Brampton, Canada. Electronic address: baileyd@dynacare.ca.
    • Clin. Biochem. 2020 Dec 1; 86: 1-7.

    AbstractClinical laboratories across the world are working to validate and perform testing for SARS-CoV-2 antibodies. Herein, we present interim consensus guidance for Canadian clinical laboratories testing and reporting SARS-CoV-2 serology, with emphasis on the capabilities and limitations of these tests and recommendations for interpretative comments in an effort to achieve harmonized laboratory practices. The consensus document provides a broad overview of topics including sample type and contamination risk; kinetics of antibody response to COVID-19 and the impact on serology testing; clinical utility of SARS-CoV-2 serology testing; clinical performance of commercial laboratory-based assays commonly deployed in North America; recommendations for interim reporting; utility of SARS-CoV-2 antibody testing for pediatric patients; and utility of point-of-care testing. The information is based on the current literature and is subject to change as additional information becomes available.Copyright © 2020. Published by Elsevier Inc.

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