• Nan G Ring, Brittany G Craiglow, Gauri Panse, Richard J Antaya, Kurt Ashack, Richard Ashack, Esteban F Faith, Amy S Paller, Jennifer M McNiff, Keith A Choate, and Christine J Ko.
• Department of Dermatology, Yale University, New Haven, Connecticut.
• J. Cutan. Pathol. 2020 May 1; 47 (5): 425-430.

BackgroundPathogenic mutations in caspase recruitment domain-containing protein 14 (CARD14) lead to CARD14-associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14-associated papulosquamous eruption.MethodsThis retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14-associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris.ResultsLesional skin biopsies from patients with CARD14-associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging.ConclusionCARD14-associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

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