• José Pacheco-Romero, Oscar Acosta, Doris Huerta, Santiago Cabrera, Marlene Vargas, Pedro Mascaro, Moisés Huamán, José Sandoval, Rudy López, Julio Mateus, Enrique Gil, Enrique Guevara, Nitza Butrica, Diana Catari, David Bellido, Gina Custodio, and Andrea Naranjo.
• Universidad Nacional Mayor de San Marcos, Faculty of Medicine. Medicina y Genética Molecular Materno Perinatal-MEGEMAPE Research Group, Lima, Peru. Universidad Nacional Mayor de San Marcos Universidad Nacional Mayor de San Marcos Faculty of Medicine Medicina y Genética Molecular Materno Perinatal-MEGEMAPE Research Group Lima Peru.
• Colomb Medica. 2021 Feb 26; 52 (1): e2014437e2014437.

BackgroundPreeclampsia is a multiorgan disorder associated with maternal and perinatal morbi-mortality. In Peru, incidence is 10% and accounts for 22% of maternal deaths. Genome and genetic epidemiological studies have found an association between preeclampsia and genetic polymorphisms.ObjectiveTo determine the association of the vascular endothelial growth factor (VEGF) +936 C/T and +405 G/C, interleukine-6 (IL-6) -174 G/C, IL-1β-511 C/T, Apo A-1-75 G/A, Apo B-100 2488 C/T (Xbal) polymorphisms with preeclampsia in pregnant Peruvian women.MethodsWere included preeclamptic and healthy (control) pregnant women. Maternal blood samples were subjected to DNA extraction, and molecular genetic analysis was conducted using the PCR-RFLP technique and following a specific protocol for each gene. Allele and genotypic frequencies in the cases and controls were compared.ResultsNo association was found between the VEGF+936C/T and VEGF+405 polymorphisms and preeclampsia. The frequencies of the GG genotypes and the G allele of the -174 G/C polymorphism in the IL6 gene in preeclamptic and controls showed significant differences, with higher frequencies in cases. For the -511 C/T polymorphism of the IL-1β gene, no significant differences were found in the frequencies of TT genotypes compared with CT+CC. The genotypes and alleles of the Apo-A1-75 G/A and Apo-B100 Xbal variants showed no significant differences between cases and controls.ConclusionNo association was found between the studied genetic markers and preeclampsia. However, in the -174G/C polymorphism of the IL-6 gene, significant differences were found mainly in the GG genotype and G allele.Copyright © 2021 Colombia Medica.

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