• Anjana Bairagi, Bronwyn Griffin, Tara Banani, Steven M McPhail, Roy Kimble, and Zephanie Tyack.
• Centre for Children's Burns and Trauma Research, Centre for Children's Health Research and Pegg Leditschke Children's Burns Centre, Queensland Children's Hospital, Brisbane, Queensland, Australia; Queensland University of Technology, Burns and Trauma Research, Centre for Children's Health Research, Brisbane, Queensland, Australia. Electronic address: a.bairagi@qut.edu.au.
• Burns. 2021 Sep 1; 47 (6): 1225-1240.

BackgroundThis systematic review evaluated the efficacy of autologous skin cell suspensions (ASCS) on the re-epithelialization of partial thickness burn injuries and skin graft donor site wounds.MethodsFour databases (EMBASE, Google Scholar, MEDLINE, Web of Science), grey literature and select journal hand-searching identified studies from 1975 - 2020. Randomized trials evaluating partial thickness burn management with non-cultured ASCS compared to any other intervention were included. Time to re-epithelialization (TTRE) was the primary outcome. Three independent researchers completed screening, data extraction and certainty of evidence assessment using Cochrane Risk of Bias Tool and Grading of Recommendations Assessment, Development and Evaluation.ResultsFive trials (n = 347) reported on adults (2 trials) and children (1 trial) with burn wounds, and adults with donor site wounds (2 trials). The effect of ASCS compared to control on TTRE in adult burn wounds was not estimable. TTRE was shorter in pediatric burn wounds (SMD -1.75 [95% CI: -3.45 to -0.05]) and adult donor site wounds (SMD-5.71 [95% CI: -10.61 to-0.81]) treated with ASCS. The certainty of evidence was very low.ConclusionCompared to standard care, ACSC may reduce pediatric partial thickness burn wound and adult split-thickness skin graft donor site TTRE.RegistrationPROSPERO CRD42019133171.Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.

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