• J. Cardiovasc. Pharmacol. · Jul 2020

    Review

    Anakinra in Recurrent Pericarditis: Current Evidence on Clinical Use, Effectiveness, and Safety.

    • Eduardo Thadeu de Oliveira Correia, Letícia Mara Dos Santos Barbetta, João Paulo Chevrand Latini de Almeida, and Evandro Tinoco Mesquita.
    • Deparment of Clinical Medicine, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil.
    • J. Cardiovasc. Pharmacol. 2020 Jul 1; 76 (1): 42-49.

    AbstractAnakinra is a recombinant human interleukin 1 receptor antagonist that competes and blocks the biologic effects of interleukin 1, reducing systemic inflammatory responses. In the 2015 guidelines for the diagnosis and management of pericardial diseases of the European Society of Cardiology, anakinra was established as a third-line therapy option for refractory recurrent pericarditis (RP). Recently, important studies that investigates the effect and safety of anakinra in RP were published, such as the AIRTRIP trial and the International Registry of Anakinra for Pericarditis. This article presents the current evidence about the effectiveness and safety of anakinra in RP and discusses its clinical application and mechanisms.

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