• Yu-Hua Huang, Tzu-Ming Yang, Yu-Jun Lin, Nai-Wen Tsai, Wei-Che Lin, Hung-Chen Wang, Wen-Neng Chang, and Cheng-Hsien Lu.
• Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
• Neurocrit Care. 2011 Apr 1; 14 (2): 253-9.

BackgroundSeizures are important neurologic complications of chronic subdural hematoma (CSDH). A better understanding of risk factors of seizures following CSDH is needed to identify the patient who will require treatment.MethodsThis one-year retrospective study enrolled 100 adult CSDH patients. Baseline prognostic variables were analyzed by Cox's proportional hazards model after a minimum of 18 months of follow-up.ResultsSeizures occurred in 11 CSDH patients, including acute symptomatic seizures in 6.0% (6/100) and unprovoked seizures in 5.0% (5/100). None progressed to status epilepticus during hospitalization. After a minimum of 18 months of follow-up, the mean Glasgow Outcome Scores (GOSs) were 4.1 ± 1.4 and 4.7 ± 0.7 for patients with and without seizures, respectively. Cox's proportional hazards model showed that only the mean GCS on admission (P = 0.004, OR = 0.78, 95% CI = 0.67-0.93) was independently associated with seizures, and a decrease of one mean GCS increased the seizure rate by 21.6%.ConclusionLower mean GCS on admission is independently predictive of seizures, most of which occur within the first three months after CSDH.

23 keywords...

hide…