• Pietro Spennato, Claudio Ruggiero, Ferdinando Aliberti, Maria Consiglio Buonocore, Vincenzo Trischitta, and Giuseppe Cinalli.
• Department of Pediatric Neurosurgery, Santobono-Paulipon Pediatric Hospital, Naples, Italy.
• World Neurosurg. 2013 Feb 1;79(2 Suppl):S20.e1-7.

BackgroundInterhemispheric and quadrigeminal cysts are rare lesions, similar in their propensity to present in young babies and to be associated with other central nervous system malformations, such as corpus callosum agenesia, holoprosencephaly, encephalocele, and neuronal heterotopias. Recently endoscopy has become increasingly popular in the treatment of arachnoid cysts, but experience with cysts located in the interhemispheric fissure and in the quadrigeminal cistern is limited.MethodsThis study reviews the specific anatomy of interhemispheric and quadrigeminal cysts and their relationship with the ventricular system and subarachnoid cisterns to select the most appropriated treatment. It also reviews the literature on endoscopic treatment of interhemispheric and quadrigeminal cysts.ResultsInterhemispheric and quadrigeminal cysts are not homogeneous, they have different extensions toward surrounding regions. In most cases it is presented as an area of contiguity between the cyst and ventricular system and/or subarachnoid cisterns, making endoscopic treatment feasible. The success rate for endoscopic treatment is not different from that reported in large series of arachnoid cysts elsewhere.ConclusionsEndoscopic treatment should be considered the first-line option in the treatment of such lesions, even if some complications, such as subdural collections due to thinness of the cerebral mantle or subcutaneous CSF collections due to multifactorial associated hydrocephalus, must be expected.Copyright © 2013 Elsevier Inc. All rights reserved.

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