• Andrade Almir Ferreira de AF Division of Neurosurgery, University of São Paulo Medical School, São PauloSP, Brazil., Matheus Schmidt Soares, Gustavo Cartaxo Patriota, Alessandro Rodrigo Belon, Wellingson Silva Paiva, Edson Bor-Seng-Shu, Oliveira Marcelo de Lima Mde L, Clarissa Nóbrega Nascimento, Gustavo Sousa Noleto, Aderaldo Costa Alves Junior, Eberval Gadelha Figueiredo, José Pinhata Otoch, and Manoel Jacobsen Teixeira.
• Division of Neurosurgery, University of São Paulo Medical School, São PauloSP, Brazil.
• Arq Neuropsiquiatr. 2013 Oct 1; 71 (10): 802-6.

ObjectiveIntracranial hypertension (IH) develops in approximately 50% of all patients with severe traumatic brain injury (TBI). Therefore, it is very important to identify a suitable animal model to study and understand the pathophysiology of refractory IH to develop effective treatments.MethodsWe describe a new experimental porcine model designed to simulate expansive brain hematoma causing IH. Under anesthesia, IH was simulated with a balloon insufflation. The IH variables were measured with intracranial pressure (ICP) parenchymal monitoring, epidural, cerebral oximetry, and transcranial Doppler (TCD).ResultsNone of the animals died during the experiment. The ICP epidural showed a slower rise compared with parenchymal ICP. We found a correlation between ICP and cerebral oximetry.ConclusionThe model described here seems useful to understand some of the pathophysiological characteristics of acute IH.

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