• Michele Reibaldi, Andrea Russo, Teresio Avitabile, Maurizio G Uva, Livio Franco, Antonio Longo, Mario D Toro, Gilda Cennamo, Cesare Mariotti, Piergiorgio Neri, Nicola D Noci, and Vincenzo Russo.
• *Department of Ophthalmology, University of Catania, Catania, Italy; †Department of Ophthalmology, University of Napoli, Naples, Italy; ‡Department of Ophthalmology, University of Ancona, Ancona, Italy; and §Department of Ophthalmology, University of Foggia, Foggia, Italy.
• Retina (Philadelphia, Pa.). 2014 Mar 1; 34 (3): 490-6.

PurposeTo report the use of bevacizumab in patients with Vogt-Koyanagi-Harada disease and persistent serous retinal detachment during the systemic steroid treatment.MethodsFour patients with bilateral Vogt-Koyanagi-Harada disease with the resolution of ocular inflammation presenting a serous retinal detachment involving the fovea that persisted for at least 1 month, despite systemic corticosteroid treatment, received an intravitreal injection of bevacizumab during the steroid tapering stage. Best-corrected visual acuity, central retinal thickness, and macular sensitivity were evaluated.ResultsOf 8 eyes, 7 (87%) had complete resolution of subretinal fluid within 1 month following the treatment. After the treatment, the mean best-corrected visual acuity and macular sensitivity improved significantly (P < 0.001, analysis of variance). Compared with baseline, at all measurements, central retinal thickness decreased significantly (P < 0.01, Tukey-Kramer test). At 6 months, a significant correlation was found between best-corrected visual acuity and macular sensitivity in the central 8° (linear regression, r = -0.73; P = 0.03), whereas no correlation was found between central retinal thickness and both best-corrected visual acuity and macular sensitivity.ConclusionIntravitreal injection of bevacizumab during the corticosteroid therapy may be a treatment option for patients with decreased visual function because of persistent serous retinal detachment associated with Vogt-Koyanagi-Harada syndrome.

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