• Int. J. Clin. Pract. · Aug 2021

    Association of urate-lowering drugs with the risk of future urolithiasis in patients with gout: a population-based nested case-control study.

    • Sheng-Wen Wu, Chin-Yin Liu, Chih-Jung Yeh, Yu-Hsun Wang, and Cheng-Chung WeiJamesJDepartment of Allergy, Immunology and Rheumatology, Chung Shan Medical University Hospital and Graduate Institute of Integrated Medicine, China Medical University and Institute of Medicine, College of medicine, Chung Shan Medical Univ.
    • Division of Nephrology, Chung Shan Medical University Hospital and School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    • Int. J. Clin. Pract. 2021 Aug 1; 75 (8): e14283.

    BackgroundPatients with gout have an increased risk of urolithiasis and usually need urate-lowering therapy (ULT) for the prevention of disease progression. However, there is a paucity of clinical data regarding the risk of future urolithiasis in ULT users.MethodsThis nested case-control study was performed using the Taiwan National Health Insurance Research Database. The aim of this study was to examine whether ULT (xanthine oxidase inhibitors [XOIs] or uricosuric agents) is associated with risk of future urolithiasis in patients with gout. Data were collected from January 2000 to December 2012.ResultsThis study included 2307 case patients and 2307 matched controls. Case patients had gout that developed into urolithiasis, and control patients had gout but were not diagnosed with urolithiasis during the study period. Patients had a mean age of 56.3 years at diagnosis of gout, and 83.2% were male patients. No association was detected between use of XOIs or uricosuric agents and risk of future urolithiasis. Furthermore, there was no significant difference in the risk of future urolithiasis in patients exposed to various cumulative days of XOI or uricosuric prescriptions.ConclusionThe present study provides evidence that neither XOIs nor uricosuric agents are associated with risk of future urolithiasis in patients with gout. Before the availability of more clinical evidence, ensuring high fluid intake and prospective monitoring of urolithiasis development are still important for uricosuric agent users.© 2021 John Wiley & Sons Ltd.

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