• Int. J. Clin. Pract. · Aug 2021

    Randomized Controlled Trial

    Serum TNF-α, IL-1β, and IL-6 Levels in Chronic HBV-Infected Patients.

    • Muhammed Bekçibaşı, Özcan Deveci, Abdullah Oğuz, Fatma Bozkurt, Saim Dayan, and Mustafa Kemal Çelen.
    • Department of Infectious Diseases and Clinical Microbiology, Bismil State Hospital, Diyarbakır, Turkey.
    • Int. J. Clin. Pract. 2021 Aug 1; 75 (8): e14292.

    BackgroundThe objective of the study was to evaluate the serum levels of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 in chronic HBV-infected patients.MethodsThe present study was a single centre, prospective and randomised controlled trial. Twenty healthy volunteers and thirty HBeAg-negative patients with planned liver biopsy and treatment-naive diagnosed with chronic hepatitis B (CHB) were included in the study. TNF-α, IL-1β and IL-6 levels were measured in the serum of CHB patient and control groups using an ELISA. Results were compared statistically using a Mann-Whitney U test.ResultsThe mean age of the CHB group (20 men, 10 women) and the control group (10 men, 10 women) was 33.3 ± 9.7 (17-55) and 26.1 ± 12.3 (16-57), respectively. When the two groups were compared with the Mann-Whitney U-test, TNF-α and IL-6 levels were found to be significantly higher in the CHB group compared to the control group (P = .003, P < .0001, respectively). Although IL-1β levels were not statistically significant, they were higher in the CHB group compared to the controls (P = .07).ConclusionsThe results of our study showed that serum levels of TNF-α and IL-6 are increased in CHB patients.© 2021 John Wiley & Sons Ltd.

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