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Int. J. Clin. Pract. · Aug 2021
Detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is Influenced by the Type of Transport Medium: Implications for Diagnosis and Monitoring.
- Nikhil Patkar, Sweta Rajpal, Nitin Shetty, Anant Gokarn, Sumeet Mirgh, Shesheer Munipally, Sudhir Nair, Amit Joshi, Vedang Murthy, Navin Khattry, and Sudeep Gupta.
- ACTREC, Navi Mumbai, India.
- Int. J. Clin. Pract. 2021 Aug 1; 75 (8): e14311.
AbstractIt is unclear if the use of a molecular transport medium (MTM) containing guanidine isothiocyanate (GITC) would be advantageous over the CDC recommended, commonly used viral transport medium (VTM). We retested 70 SARS-CoV2 cases by RT-PCR in varying stages of follow-up using MTM and VTM in parallel and found discrepant results of RNase P, E and N genes. Majority (81%) patients tested positive with MTM as compared with VTM (27.1%). Even patients who were sampled 3 weeks after diagnosis demonstrated a significant discrepancy in the positivity rates between MTM vs VTM raising concerns about the clinical utility of VTM.© 2021 John Wiley & Sons Ltd.
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