• Wen-Tian Lyu, Qi-Bin Song, Wang Qiong, Jing Liu, Ren Yong, Feng-Tao Yi, and Dong-Liang Han.
• Department of Oncology, Huanggang Center Hospital, Huangzhou District, Huanggang.
• Medicine (Baltimore). 2021 May 7; 100 (18): e25770e25770.

IntroductionCD30+ primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a rare T-cell neoplasm, and has been reported to present with an indolent behavior. The PC-ALCL with aggressive behavior has not been reported in the literature.Patient ConcernsWe treated a patient with PC-ALCL that exhibited indolent behavior in the past 2 years and aggressive behavior within the last 3 months before presentation.DiagnosisAggressive CD30+ primary cutaneous anaplastic large cell lymphoma.InterventionsThe radiotherapy regimen was individualized in terms of the target volume delineation and dose prescription, and the dose-response relationship was evaluated.OutcomesThe mean distance of microscopic infiltration was 14.1 mm in depth and 14.3 mm circumferentially. The lesion completely regressed after the delivery of 40 Gy in 20 fractions over 4 weeks. The tumor did not recur over the next year.ConclusionAn aggressive disease course is rare for indolent CD30+ PC-ALCL, which has similar histopathological characteristics as indolent PC-ALCL. The radiotherapy strategy should be individualized with curative intent.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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