• Science · Apr 1974

    Somatostatin: hypothalamic inhibitor of the endocrine pancreas.

    • D J Koerker, W Ruch, E Chideckel, J Palmer, C J Goodner, J Ensinck, and C C Gale.
    • Science. 1974 Apr 26; 184 (4135): 482-4.

    AbstractSomatostatin, a hypothalamic peptide that inhibits the secretion of pituitary growth hormone, inhibits basal insulin secretion in fasted cats and rats. In fasted baboons both basal and arginine-stimulated secretion of insulin and glucagon are inhibited. Somatostatin appears to act directly on the endocrine pancreas. The action is dose-related, rapid in onset, and readily reversed.

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