• Vaccine · Mar 2012

    Randomized Controlled Trial Multicenter Study Comparative Study

    Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine.

    • Benjamin P Sablan, Dong Joon Kim, Nina G Barzaga, Wan Cheng Chow, Mong Cho, Sang Hoon Ahn, Seong Gyu Hwang, Ji Hyun Lee, Hamid Namini, and William L Heyward.
    • Out-Patient Department, Philippine General Hospital, Manila, Philippines.
    • Vaccine. 2012 Mar 30; 30 (16): 2689-96.

    AbstractAdults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS) adjuvant, combined with recombinant hepatitis B surface antigen (HBsAg) demonstrated faster, superior, and more durable seroprotection than three doses of a licensed comparator HBV vaccine (Engerix-B(®)). This investigational vaccine, HBsAg-1018 ISS, was well tolerated with a safety profile similar to the comparator vaccine. These results suggest that HBsAg-1018 may be more effective in this hypo-responsive population.Copyright © 2012 Elsevier Ltd. All rights reserved.

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