• Zhen-Hua Lu and Xiao-Qin Kang.
• Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
• Medicine (Baltimore). 2019 Apr 1; 98 (17): e15316e15316.

BackgroundThis systematic review will assess the effectiveness of advanced nursing care (ANC) on depression in patients with ovarian cancer (OC).MethodsWe will identify any relevant randomized controlled trial from Cochrane Library, MEDLINE, Embase, Web of Science, Springer, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from their inceptions to March 5, 2019. The primary outcome includes depression. The secondary outcomes consist of anxiety, quality of life, and adverse events. Data that meets all the eligibility criteria will be extracted, pooled, and analyzed by using RevMan 5.3 software. Methodological quality for each eligible study will be assessed by using Cochrane risk of bias tool.ResultsThis study will analyze depression, anxiety, quality of life, and adverse events of ANC on depression in patients with OC.ConclusionThe findings of this study will provide the latest evidence for the effectiveness and adverse events of ANC on depression in patients with OC.Ethics And DisseminationNo ethic approval is required for this study, because all the data will be extracted from previous published studies. The results of this study will be presented at conference or will be published at a peer-reviewed journal.Prospero Registration NumberPROSPERO CRD42019126374.

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