• Angelo Franzini, Giovanni Broggi, Roberto Cordella, Ivano Dones, and Giuseppe Messina.
• Department of Neurosurgery, Fondazione IRCCS Istituto Nazionale Neurologico Carlo Besta, Milan, Italy.
• World Neurosurg. 2013 Sep 1;80(3-4):S29.e11-4.

ObjectiveTo describe our institutional experience with deep-brain stimulation (DBS) used in the treatment of aggressive and disruptive behavior refractory to conservative treatment.MethodsWith stereotactic methodology and under general anesthesia, seven patients (from 2002 to 2010) were given DBS in the posterior hypothalamic region, bilaterally, and with the aid of intraoperative microrecording.ResultsSix of seven patients presented a clear reduction in the aggression and disruptive bouts, with subsequent simplification of familiar management.ConclusionsDBS of the posterior hypothalamic region could be an effective treatment for patients affected by mental retardation in whom disruptive and drug-refractory aggressive behavior coexists. Although several experimental data are available on this target, further studies are necessary to confirm the long-term efficacy and safety of this procedure.Copyright © 2013. Published by Elsevier Inc.

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