• Saniye Göknil Çalık, Mustafa Çalık, Arslan KaşdoğanZümrüt ElaZE0000-0001-6808-5715Department of Anesthesiology and Reanimation, Health Sciences University, Konya Training and Research Hospital, Konya, Turkey, Mustafa Cihat Avunduk, Olgun Kadir Arıbaş, and Hidir Esme.
• DepartmentofEmergencyandFirstAid,VocationalSchoolofHealthServices,KTOKaratay University,Konya,Turkey
• Turk J Med Sci. 2020 Apr 30; 51 (2): 857863857-863.

Background/AimWe aimed to investigate the topical application of mitomycin-C (MMC) after the conventional tracheostomy in a rabbit model.Materials And MethodsTwenty-four male New Zealand White rabbits were randomly divided among 3 equal groups (n: 8). Trache- ostomies were performed on 16 subjects. Group 1 which served as a control for all tracheal measurements. After tracheostomy, we applied sterile saline (group 2) or MMC at 0.8 mg/mL (group 3) around the tracheotomy site for 5 min. At the 3rd week after surgery, all tracheas were subjected to morphometric and histopathological examinations, including tracheal lumen diameter (LD), number of capillary vessels (CV), subepithelial tissue thickness (SETT), fibroblasts, and inflammatory cells (IC).ResultsThere was a statistically significant difference between the two tracheostomy groups themselves and the control group for LD (p = 0.035), CV (p = 0.006), SETT, fibroblasts, and IC (p < 0.001). Histopathological analysis showed the decreased LD, CV, SETT, IC, and fibroblasts compared to MMC with tracheostomy groups. MMC was more effective than saline for LD, CV, SETT, IC, and fibroblasts.ConclusionWound healing modulation may prevent scar formation. Fibrosis decreased following tracheostomy in the group treated with MMC. Fibroblasts appear to be key cells mediating these effects.This work is licensed under a Creative Commons Attribution 4.0 International License.

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