• Revista clínica española · Apr 2022

    Case Reports

    [Meta-analysis evaluating the risk of respiratory tract infections and acute respiratory distress syndrome with glucagon-like peptide-1 receptor agonists in cardiovascular outcome trials: useful implications for the COVID-19 pandemic].

    • D Patoulias, A Boulmpou, K Imprialos, K Stavropoulos, C Papadopoulos, and M Doumas.
    • Second Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, General Hospital «Hippokration», Thessaloniki, Grecia.
    • Rev Clin Esp. 2022 Apr 1; 222 (4): 229-232.

    AbstractPatients with type 2 diabetes mellitus (T2DM) are at increased risk for severe coronavirus disease 2019 (COVID-19) and related mortality. Glucagon-like peptide-1 receptor agonists (GLP-1-RAs) have significant cardiovascular and renal benefits for patients with T2DM and related comorbidities. Their anti-inflammatory properties could be beneficial in these patients. This work provides less-biased estimates regarding the risk for respiratory tract infections and acute respiratory distress syndrome by performing the first significant meta-analysis of cardiovascular outcome trials in the literature. Notably, GLP-1-RAs do not seem to increase the risk for respiratory tract infection, pneumonia, or acute respiratory distress syndrome in patients with T2DM and cardiovascular comorbidities.© 2021 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI). All rights reserved.

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