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Médecine sciences : M/S · Dec 2009
Review[Monoclonal antibodies targeting VEGF in ophthalmology: the case of exudative age-related macular degeneration].
- Nicolas Leveziel, Gisèle Soubrane, and Eric H Souied.
- Service d'ophtalmologie (Pr Eric Souied), Hôpital intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France. nicolas.leveziel@yahoo.fr
- Med Sci (Paris). 2009 Dec 1; 25 (12): 1105-7.
AbstractAge-related macular degeneration (AMD) is the main cause of vision loss in the elderly in developed countries. The exudative AMD is the most frequent and severe form of the disease, leading to a rapid loss of vision. The results of MARINA and ANCHOR studies, two multicentric clinical trials analyzing the efficacy of anti-VEGF in exudative AMD, have showed that this modality of treatment results in a stabilisation of the visual acuity in most cases (70%), and in visual improvement in 30 % of the cases. Up till now, the anti-VEGF approach represents a major step in the therapeutic strategy of this disease.
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