• Ida K Fox, Kristen M Davidge, Christine B Novak, Gwendolyn Hoben, Lorna C Kahn, Neringa Juknis, Rimma Ruvinskaya, and Susan E Mackinnon.
• St. Louis, Mo.; and Toronto, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, Department of Surgery, the Division of Neurorehabilitation, Spinal Cord Injury Program, and the Department of Neurology, Washington University School of Medicine; the Milliken Hand Center of The Rehabilitation Institute of Saint Louis; and the Hand and Upper Extremity Program, Division of Plastic and Reconstructive Surgery, Hospital for Sick Children.
• Plast. Reconstr. Surg. 2015 Oct 1; 136 (4): 780-792.

BackgroundCervical spinal cord injury can result in profound loss of upper extremity function. Recent interest in the use of nerve transfers to restore volitional control is an exciting development in the care of these complex patients. In this article, the authors review preliminary results of nerve transfers in spinal cord injury.MethodsReview of the literature and the authors' cases series of 13 operations in nine spinal cord injury nerve transfer recipients was performed. Representative cases were reviewed to explore critical concepts and preliminary outcomes.ResultsThe nerve transfers used expendable donors (e.g., teres minor, deltoid, supinator, and brachialis) innervated above the level of the spinal cord injury to restore volitional control of missing function such as elbow extension, wrist extension, and/or hand function (posterior interosseous nerve or anterior interosseous nerve/finger flexors reinnervated). Results from the literature and the authors' patients (after a mean postsurgical follow-up of 12 months) indicate gains in function as assessed by both manual muscle testing and patients' self-reported outcomes measures.ConclusionsNerve transfers can provide an alternative and consistent means of reestablishing volitional control of upper extremity function in people with cervical level spinal cord injury. Early outcomes provide evidence of substantial improvements in self-reported function despite relatively subtle objective gains in isolated muscle strength. Further work to investigate the optimal timing and combination of nerve transfer operations, the combination of these with traditional treatments (tendon transfer and functional electrical stimulation), and measurement of outcomes is imperative for determining the precise role of these operations.Clinical Question/Level Of EvidenceTherapeutic, IV.

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